Abstract:
The aim of this thesis is to show how the structure of the two naturally occurring substances, chamic acid, and chaminic acid can be verified synthetically by using an intermediate of the 7,7-dimethylbicyclo-[4,1,0] - heptan-2-one (7,7-dimethylnorcarone) type. The main object of the present work is to find a method for synthesising this intermediate.
The route chosen consists of saturating the benzene ring of a suitably substituted derivative of benzoic acid with the view to eventually closing the ring giving rise to a bicyclic compound containing the cyclopropane and the cyclohexanone ring systems.
The probable stereochemistry of chamic acid is also discussed.
