Aspects of the Metabolism of Crotyl Phosphate

Abstract

The metabolism of crotyl phosphate is of interest for a number of reasons. Primarily to determine whether it is a substrate for the glutathione-S-transferases described by Boyland and Chasseaud (1967, 1968) and, if so, the nature and direction of the conjugation with glutathione. It is also of interest to compare the metabolism of crotyl compounds with that of the homologous allyl compounds which are known to give rise to mercapturic acids (N-acetylated S-substituted cysteines) as shown by Clapp, Kaye and Young (1969). I. The Occurrence of S-Substituted Cysteines A number of S-substituted cysteines have been found in small amounts as excretion products of animals. Although most of these have also been found in plants, in only a few cases has the excretion product been traced to the diet of the animal.