dc.rights.license |
Creative Commons GNU GPL |
en_NZ |
dc.contributor.advisor |
Ellenbroek, Bart |
|
dc.contributor.author |
Waddington, Claire |
|
dc.date.accessioned |
2016-05-20T05:00:08Z |
|
dc.date.accessioned |
2022-11-03T19:11:46Z |
|
dc.date.available |
2016-05-20T05:00:08Z |
|
dc.date.available |
2022-11-03T19:11:46Z |
|
dc.date.copyright |
2016 |
|
dc.date.issued |
2016 |
|
dc.identifier.uri |
https://ir.wgtn.ac.nz/handle/123456789/29919 |
|
dc.description.abstract |
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a number of contributing genetic and environmental factors. While a number of studies have looked at the negative environmental factors underpinning ASD, few have investigated the ameliorating effects of a combination of positive environmental treatments and genetic factors. The current study investigated whether 24 hours of maternal deprivation (MD, constituting a negative environment) on PND9, in combination with the serotonin transporter knockout (SERT KO) genotype would increase the autistic-like characteristics of male Wistar rats, and additionally, whether early handling (EH, constituting a positive environment) from PND2-14 in combination with the same genotype would decrease these behaviours. Five experiments were used: social interaction, social approach and avoidance, scent marking, hole dipping and reversal learning. The results showed that SERT KO MD rats have autistic-like social impairments, while the SERT KO EH rats show improvements on social and communicative tasks, indicating that, in some behavioural measures, both positive and negative environmental factors have a significant influence on the SERT KO genotype. These results highlight the importance of serotonin and early-life stress in the development of ASD, as well as the role of positive environmental factors in the treatment of this disorder. |
en_NZ |
dc.format |
pdf |
en_NZ |
dc.language |
en_NZ |
|
dc.language.iso |
en_NZ |
|
dc.publisher |
Te Herenga Waka—Victoria University of Wellington |
en_NZ |
dc.rights |
Access is restricted to staff and students only. For information please contact the Library. |
en_NZ |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/3.0/nz/ |
|
dc.subject |
SERT |
en_NZ |
dc.subject |
ASD |
en_NZ |
dc.subject |
Autism |
en_NZ |
dc.subject |
Plasticity |
en_NZ |
dc.subject |
Autism Spectrum Disorder |
en_NZ |
dc.subject |
Serotonin transporter |
en_NZ |
dc.subject |
Serotonin transporter knockout |
en_NZ |
dc.title |
The Good, the Bad and the Plasticity Genes: The Role of both Positive and Negative Environmental Factors and the SERT KO Genotype on the Development of ASD-Like Symptoms in a Rodent Model |
en_NZ |
dc.type |
Text |
en_NZ |
dc.date.updated |
2016-05-20T03:54:00Z |
|
vuwschema.contributor.unit |
School of Psychology |
en_NZ |
vuwschema.subject.anzsrcfor |
170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) |
en_NZ |
vuwschema.subject.anzsrctoa |
3 APPLIED RESEARCH |
en_NZ |
vuwschema.type.vuw |
Awarded Research Masters Thesis |
en_NZ |
thesis.degree.discipline |
Cognitive and Behavioural Neuroscience |
en_NZ |
thesis.degree.grantor |
Te Herenga Waka—Victoria University of Wellington |
en_NZ |
thesis.degree.level |
Masters |
en_NZ |
thesis.degree.name |
Master of Science |
en_NZ |