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Synthesis of N-Glycans Implicated in Asthma and Allergy

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dc.contributor.advisor Timmer, Mattie
dc.contributor.advisor Stocker, Bridget
dc.contributor.author Haslett, Gregory William
dc.date.accessioned 2011-11-18T03:10:25Z
dc.date.accessioned 2022-10-31T21:06:12Z
dc.date.available 2011-11-18T03:10:25Z
dc.date.available 2022-10-31T21:06:12Z
dc.date.copyright 2011
dc.date.issued 2011
dc.identifier.uri https://ir.wgtn.ac.nz/handle/123456789/27049
dc.description.abstract Asthma and allergies affect a large number of people, with over 300 million people worldwide suffering from asthma alone. Although, on the ‟macroscopic‟ level, it is known how allergens trigger allergic reactions, it is not known how an allergen's ‟micro‟ structure causes such a profound allergic response in sensitised individuals. A review of inter-species carbohydrate motifs revealed a striking similarity between carbohydrate moieties (N-glycans) present on antigens derived from species known to give an allergic T helper (Th) 2 response in humans (such as pollen, schistosomes, and food allergens). Preliminary studies on mixtures of allergen extracts have suggested that these carbohydrate motifs (glycoproteins) bias the immune response to an allergic (Th2) response. This project presents work conducted towards the synthesis of three fragments of a larger N-glycan found on allergens. The synthesis of these N-glycans will allow the first detailed study regarding the relationship between N-glycan structure and Th2 bias to be performed and thereby aid in our understanding of the molecular triggers of asthma. Ultimately, this could lead to the elucidation of the mechanisms of the allergic Th2 immune response. en_NZ
dc.format pdf en_NZ
dc.language en_NZ
dc.language.iso en_NZ
dc.publisher Te Herenga Waka—Victoria University of Wellington en_NZ
dc.rights This thesis is embargoed until 5 October 2012. It will be made available after this date. en_NZ
dc.subject N-Glycans en_NZ
dc.subject Asthma en_NZ
dc.subject Allergy en_NZ
dc.title Synthesis of N-Glycans Implicated in Asthma and Allergy en_NZ
dc.type Text en_NZ
vuwschema.contributor.unit School of Chemical and Physical Sciences en_NZ
vuwschema.subject.marsden 320201 Allergy en_NZ
vuwschema.subject.marsden 320305 Medical Biochemistry: Proteins and Peptides en_NZ
vuwschema.type.vuw Awarded Research Masters Thesis en_NZ
thesis.degree.discipline Chemistry en_NZ
thesis.degree.grantor Te Herenga Waka—Victoria University of Wellington en_NZ
thesis.degree.level Masters en_NZ
thesis.degree.name Master of Science en_NZ

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