DSpace Repository

A study of picrotoxin chemistry and some of its derivatives

Show simple item record

dc.contributor.author Gee, Roy
dc.date.accessioned 2011-03-10T23:01:35Z
dc.date.accessioned 2022-10-25T05:17:23Z
dc.date.available 2011-03-10T23:01:35Z
dc.date.available 2022-10-25T05:17:23Z
dc.date.copyright 1951
dc.date.issued 1951
dc.identifier.uri https://ir.wgtn.ac.nz/handle/123456789/23267
dc.description.abstract Picrotoxin is the bitter convolus principle of the Coculus berry found in the East Indies. It can be resolved into two components Picrotin and Picrotoxinin, probably a loose molecular compound. Picrotoxin = Picrotin + Picrotoxinin C30H34O13 C15H18O7 C15H16O6 The chemical investigation of picrotoxin started to get a foothold in chemical literature in the latter part of the nineteenth century. From then onwards many workers in the field of picrotoxin have tried to puzzle out from the mass of derivatives, transformations and degradations some sort of structual formula for it. The latest formulae put forward,is by Conroy of Harvard University U.S.A. for the structure of picrotoxinin. More however will be said about Conroy's formula in the next section. Picrotoxin is used in medicine as an antidote for barbiturate poisoning since it arrests the saporific action of these substances, and there have been many references in recent medical journals of its success in this application. Its use for adulterating beer was known back in the middle of the nineteenth century; East Indies natives used it for poisoning fish. It would seem from the medical point of view, very interesting to know the true structure so that a less highly toxic and thus a less dangerous drug could eventually be synthesised for curative purposes. en_NZ
dc.format pdf en_NZ
dc.language en_NZ
dc.language.iso en_NZ
dc.publisher Te Herenga Waka—Victoria University of Wellington en_NZ
dc.title A study of picrotoxin chemistry and some of its derivatives en_NZ
dc.type Text en_NZ
vuwschema.type.vuw Awarded Research Masters Thesis en_NZ
thesis.degree.grantor Te Herenga Waka—Victoria University of Wellington en_NZ
thesis.degree.level Masters en_NZ

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


My Account