A highly virulent strain of the bacterium Pseudomonas syringae pv. actinidiae (Psa-V), the causative agent of bacterial canker of kiwifruit, is threatening the $1.5 billion New Zealand kiwifruit industry. A strain of Psa-V ...

Non-ribosomal peptide synthetases (NRPS) are large, modular enzymes that synthesise biologically active secondary metabolites from amino acid precursors without the need for a nucleic acid template. NRPS play an integral ...

An emerging anti-cancer strategy is the development of cancer prodrugs for targeted therapies. Nitroaromatic prodrugs have shown great promise in this regard due to the ability of the strongly electronegative nitro group ...

Bacterial nitroreductase enzymes, which exhibit the capacity to reduce a wide range of nitroaromatic drugs, antibiotics and environmental pollutants, have shown promise in the activation of prodrugs such as CB1954 and ...

Shiga-toxin producing E. coli (STEC) are increasingly recognized as agents of sporadic and outbreak associated gastroenteritis. Although E. coli O157 has traditionally been the most commonly identified STEC serotype, ...